Forskning vid Uppsala universitet

Forskningsprojekt från 2016-01-01 till 2019-12-31

A promising approach to treatment of disseminated cancer is a targeting, i.e. therapy based on specific recognition of cancer-associated molecular alteration in tumour cells. Success of the targeting therapy ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

Antibiotic resistance is increasing at an alarming rate. There is consequently an urgent need for new approaches that can define efficient dosing strategies and facilitate development of treatments against ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

This research plan describes a series of projects with an overall goal to elucidate how the amino acid transporters (SLCs) regulate neurotransmitter levels and energy metabolism in the brain.We usetransgenic ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

AIM: To understand molecular mechanisms regulating vascular abnormalization in glioblastoma and to identify vascular targets for cancer therapy. BACKGROUND: Glioblastoma are aggressive brain tumors characterized ...

Forskningsprojekt från 2018-01-01 till 2027-12-31

The aim is to explore the relationship between genetic variation and biodiversity by combining genetic screens in non-model organisms (e.g. Atlantic herring and Darwin’s finches) with functional follow ...

Forskningsprojekt från 2017-01-01 till 2017-12-31

The main mission of ELIXIR is to build a sustainable European infrastructure for biological information, supporting life-science research and its translation to society, the bio-industries, environment ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

The purpose of the project is to investigate factors influencing targeted delivery of radionuclides using engineered scaffold proteins (ESP). The ultimate goal is to provide rationale for molecular design ...

Forskningsprojekt från 2015-01-01 till 2019-12-31

Sweden has a long and proud tradition in translational medicine, with major pharmaceutical and medical technology companies and many important Swedish research studies with large impact on clinical medicine ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

Få mikroorganismer har så stor inverkan på människors och djurs hälsa som influensa A virus (IAV). IAV finns hos änder men korsar artbarriärer och infekterar tamfåglar, däggdjur och människa. Fågelvirus ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

The plant-derived molecule Thymoquinone (TQ) is promising against cancer and a drug candidate that has recently shown enhanced in vitro efficacy when formulated as nanoparticles (TQ-NPs) compared with ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

In this proposal, we will implement a cross-disciplinary research program to target glioblastoma, the most common form of brain cancer. In the affected patient, a glioblastoma expands gradually through ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

Lymphatic vasculature constitutes a network of vessels critical for the maintenance of tissue fluid homeostasis. Failure of the lymphatic system leads to chronic swelling, called lymphoedema, but it is ...

Forskningsprojekt från 2013-01-01 till 2017-12-31

This plan describes the continuation of a project, which has been ongoing in the PIs laboratory for the past ten years. The project started as a broad mapping of the glomerular transcriptome and has so ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Heparan sulfate (HS) and the structurally related heparin occur in proteoglycan form at cell surfaces, in the extracellular matrix, and in intracellular vesicles. The heterogeneous polysaccharide chains ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

For over 40 years, natural products have served us well in combating cancer. The main sources of these successful compounds are microbes and plants from the nature. A major contribution comes from plant ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Glioblastomas are highly aggressive brain tumors, characterized by microvascular proliferation and dysfunctional vessels. The abnormal vessels contribute substantially to patient mortality. Still, the ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

The lymph nodes provide a unique environment for immune activation and regulation, including antitumor responses. They arealso common sites for tumor metastasis. My own and others recent data has shownthat ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

This proposal aims at understanding molecular mechanisms of interspecies transmission of influenza A viruses (IAV) from the natural reservoir to poultry. Few viruses have affected humanity as much as IAV ...

Forskningsprojekt från 2016-04-01 till 2017-12-31

NBIS is a continuation of BILS (Bioinformatics Infrastructure for Life Sciences) now also including WABI (Wallenberg Advanced Bioinformatics Infrastr.), SILS (Systems Biology Infrastr. for Life Sciences ...

Forskningsprojekt från 2014-01-01 till 2019-12-31

Lymphatic system is composed of a hierarchy of vessels with specific features serving their unique functions: lymphatic capillaries that absorb interstitial fluid and collecting lymphatic vessels that ...

Forskningsprojekt från 2014-01-01 till 2014-12-31

Sweden has a long tradition in translational medicine, with major pharmaceutical companies and important Swedish studies with large impact on clinical medicine. However, in the past decade, this landscape ...

Forskningsprojekt från 2017-01-01 till 2019-12-31

This research proposal is about when generation of cells go wrong in retina. We will study the cancer retinoblastoma and cells that initiate a non-functional regeneration program with proliferation, which ...

Forskningsprojekt från 2017-01-01 till 2020-12-31

Cancer does not only affect the site where the tumor cells are located, but also the functionality of other organs in the body. Although tumor-induced systemic effects account for the majority of cancer-related ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

With described work we aim to clarify by which mechanisms amyloid harm cells and if amyloid can be prevented or resolved. Amyloid is cell-toxic aggregates and IAPP forms amyloid in beta-cells in type 2 ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

There is a clinical need to improve therapy of disseminated prostate cancer (PCa). My program should provide scientific rationale for the use of theranostics (agents suitable for both diagnostic and therapy ...