Forskning vid Uppsala universitet

Forskningsprojekt från 2013-01-01 till 2015-12-31

Obtaining quantitative data from live cell images is the key to understanding molecular and cellular processes. Automated microscopes enable the collection of images at a rate which outpaces researchers ...

Forskningsprojekt från 2015-01-01 till 2018-12-31

Generation of architectural polarity impacts all cell types, ranging from epithelial cells to neurons and astrocytes, relates to tissue organization and links to disease development when misregulated. ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

We propose to study the structure-function relations of the bacterial ribosome. The ribosome is a large (2.5 MD) macromolecular complex that makes peptide chains with amino acid sequences as prescribed ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Ginseng polysaccharide is a complex mixture of neutral and acidic polysaccharides that has been proven to have anticancer activities. It functions through interactions with a protein called Galectin-3. ...

Forskningsprojekt från 2019-01-01 till 2022-12-31

The main focus for this project is to understand hematopoiesis and neurogensis in crustaceans using the freshwater crayfish Pacifastacus leniusculus as a model animal. The hematopoietic tissue of crayfish ...

Forskningsprojekt från 2020-01-01 till 2022-12-31

För att effektivt fixera koldioxid kapslar cyanobakterier in Rubisco och karbonanhydras inuti en proteinorganell som kallas karboxysomen. Detta skapar en hög koncentration av koldioxid i närheten av Rubisco ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

Bacterial infections are re-emerging as a serious health threat, caused by the rampant spread of resistance mechanisms towards clinically relevant antibiotics. Intestinal pathogens of the family enterobacteriaceae ...

Forskningsprojekt från 2018-01-01 till 2021-12-31

Single cell analysis provides unprecedented opportunities to dissect and understand cells, the basic units of life. Until recently, there have been limited ways to study proteins in single cells in a high-throughput ...

Forskningsprojekt från 2013-01-01 till 2015-12-31

The origin of vertebrates was preceded by two dramatic genomic events, namely whole genome doublings or tetraploidizations. This generated numerous additional genes that have facilitated the evolution ...

Forskningsprojekt från 2021-01-01 till 2023-12-31

Currently there are no effective treatments that can cure metastatic breast cancer and therefore patients diagnosed with metastatic disease have an extremely poor prognosis. A critical program underlying ...

Forskningsprojekt från 2014-07-01 till 2017-06-30

Recent work shows that growth factor receptor signalling continues in endosomes, turning the endosomal network into a signalling platform. Different growth factors modulate the endosomal network and features ...

Forskningsprojekt från 2020-12-01 till 2023-12-31

Assessing safety of early candidates in drug discovery is currently to a large extent based on animal studies, requiring large amounts of animals every year. The purpose of this project is to validate ...

Forskningsprojekt från 2016-01-01 till 2018-12-31

This project aims to develop a 3D-based differentiation method that can be customised for specific applications. Pluripotent stem cells (PSC) have great potential in regenerative medicine, disease modelling ...

Forskningsprojekt från 2020-01-01 till 2023-12-31

Learning and long-term memory (L&M) are complex phenomena and the relationships between specific memories and molecular events in neurons are still shrouded in mystery. Our approach to unravel L&M mechanisms ...

Forskningsprojekt från 2016-01-01 till 2016-12-31

The human genome is diploid, ie consists of a maternal and a paternal set of 23 homologous chromosomes with a unique nucleotide content. Phasing (haplotyping) refers to the assignment of the order of individual ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Målet med detta projekt är att studera toxicitetsmekanismer för miljöfarliga kemikalier via intelligent datagenerering med hjälp av ett automatiserat laboratorium som styrs av ett system med artificiell ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

I have recently identified over 40 novel genes that code for new members of the solute carrier family and many of these are likely to be novel transporters fro amino acids. We have unpublished data showing ...

Forskningsprojekt från 2014-01-01 till 2016-12-31

Lymphatic vasculature constitutes a network of vessels critical for the maintenance of tissue fluid homeostasis. Failure of the lymphatic system leads to chronic swelling, called lymphoedema, but it is ...

Forskningsprojekt från 2011-04-01 till 2017-03-31

I have recently identified over 40 novel genes that code for new members of the solute carrier family and many of these are likely to be novel transporters fro amino acids. My research group are currently ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Heparan sulfate proteoglycans are ubiquitous components of cell surfaces and are also present in the extracellular matrix, predominantly in basement membranes. The proteoglycans influence embryonic development ...

Forskningsprojekt från 2011-01-01 till 2013-12-31

We will use a systems biology approach to study of the genome, epigenome, proteome, lipidome and glycome in populations from the European Special Population Research Network. Exome sequences will be determined ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

We know the sequence of the human genome and close to all of our genes but have very poor knowledge of where gene regulatory regions are located and the consequences of sequence variation in them. The ...

Forskningsprojekt från 2014-01-01 till 2017-12-31

Understanding the key forces underlying population differentiation and speciation, the forces that ultimately generate biodiversity, is a fundamental question in evolutionary biology. To address this question ...

Forskningsprojekt från 2019-01-01 till 2021-12-31

Glioblastoma (GBM) is an exceptionally aggressive and deadly cancer for which there is no cure, and contrary to many other cancers, has had very little therapeutic progress. Characteristic features of ...

Forskningsprojekt från 2012-01-01 till 2015-12-31

Aim: This project aims to investigate how oscillations are generated, and what computational function these brain rhythms have. We will dissect the role of different cell populations and different cellular ...

Forskningsprojekt från 2020-08-01 till 2020-12-31

Recent reports claim that  ribosomal RNA-binding antibiotics e.g. anisomycin, doxycyline, etc. are effective against Coronavirus (CoV), but systematic study and molecular insights are lacking.This project ...

Forskningsprojekt från 2013-01-01 till 2016-12-31

Melanization is caused by activation of the Prophenoloxidase activating system ( ProPO ) which consists of a proteolytic enzyme cascade and prophenoloxidase. When activated the ProPO-system generates several ...

Forskningsprojekt från 2018-01-01 till 2020-12-31

In silico och in vitro metoder används allt oftare i riskbedömning av kemikalier men förutsägbarheten varierar kraftigt mellan olika metoder och substansgrupper. Därför är det svårt att göra kvantitativa ...

Forskningsprojekt från 2013-01-01 till 2013-12-31

High flux coherent X-ray pulses can revolutionise the way we visualise biological events, bimolecular dynamics, and processes. Recent results show that free-electron lasers can potentially unlock the structure ...

Forskningsprojekt från 2012-01-01 till 2014-12-31

Mast cells are inflammatory cells of importance for the host defense against parasites and bacteria. They are, hovewer, primarily known for their prominent role in IgE mediated allergies. Upon activation ...